Population FBA predicts metabolic phenotypes in yeast
Fig 8
Bimodality in amino acid utilization.
(A) 2D Histogram of growth rate and threonine uptake rate shows bimodality in threonine uptake among cells growing slower than 0.4 hr−1. (B) Scatter plot showing PDC flux and threonine uptake for slow growing cells (<0.35 hr−1). Whenever GAPDH or PDC flux is bound because of protein constraint (green + and red o respectively), cells take up threonine to fuel the glycine-serine cycle and generate NADH/NADPH and ATP which otherwise would have been generated from glycolysis.