Population FBA predicts metabolic phenotypes in yeast
Fig 5
Analysis of metabolic fluxes from yeast 7.6 simulations in SD and 13C media.
(A) Glucose uptake, oxygen uptake and ethanol efflux from simulations in SD medium. (B) First PCA component showing fast growing cells performing respiration along with fermentation. (C) Second PCA component showing transport of glycine to mitochondria as part of Serine-Glycine cycle to produce NADH or NADPH which compensates for reduced NADH production due to limited fermentation due to glucose limitation (D) Third PCA component from SD medium simulations shows burning of NADH by mitochondrial alcohol dehydrogenase produced in Serine-Glycine cycle and transport of citric acid to mitochondria, all by fast growing cells.