Probing eukaryotic cell mechanics via mesoscopic simulations
Fig 4
Effects of cytoskeleton, nucleus and viscosity on whole cell model mechanics.
(a-c) The simulation results for the effect of the cytoskeleton filaments number density Nfil on elastic modulus (orange) and velocity (green) of small, medium and large size cells. (d) Influence of the cross-links NCL to filaments Nfil density ratio on elastic modulus (orange) and on velocity (green). (e) Influence of elastic modulus on the velocity for the case when the stiffness is changed by varying filaments density Nfil (green) or cross-links density NCL (orange). (f) Dependence of cell elastic modulus and velocity on nuclear-cytoplasmic ratio. (g) Effect of filaments number density representing chromatin inside the nucleus on cell velocity. (h) The impact of nuclear laminar properties varied using parameter in the nucleus membrane model on the cell velocity. (i) Effect of viscosity on cell velocity in microfluidic device. Error bars on all plots show standard deviation.