Limb-Enhancer Genie: An accessible resource of accurate enhancer predictions in the developing limb
Fig 4
Modeling limb enhancers sequence composition and its integration with chromatin information.
(A) AUROC estimated on the ten leave-one-out test sets for all the indicated models (Sequence, Chromatin or their combination, S+C). (B) Same as (A) but showing AUPRC. (C) Bar plot showing the average coefficient from the LASSO models for those sequence features selected in 9/10 of splits during LASSO training and reported in the top 25% in terms of mean decrease in accuracy, as estimated during RF training. (D) Boxplot showing the distribution of the total number of publications in limb development for the genes shown in (C) (Top, orange) as well as for those TFs whose corresponding features were selected in at least one CV-fold (but less than nine, Low, light yellow) or in none (No, grey) (outliers not shown).