Limb-Enhancer Genie: An accessible resource of accurate enhancer predictions in the developing limb
Fig 2
Limb-specific chromatin features accurately predict limb-enhancers.
(A) Box plots showing the AUROC estimated on the ten leave-one-out test sets, considering an increasingly larger set of chromatin features (left to right, outliers not shown). (B) Same as (A) but showing the AUPRC. (C) UCSC genome browser snapshots indicating two representative loci. Validated limb enhancers (bright red elements) showed different features than nearby regions that tested negative in vivo (blue). In particular, they displayed a higher DNase I enrichment (compare DNase I to Headless embryo). De novo limb-enhancers predicted based on combined models are also shown (dark red).