Polymodal allosteric regulation of Type 1 Serine/Threonine Kinase Receptors via a conserved electrostatic lock

doi:10.1371/journal.pcbi.1005711

Polymodal allosteric regulation of Type 1 Serine/Threonine Kinase Receptors via a conserved electrostatic lock

Fig 2

Salt bridge distance between R375(Cζ) and D354 (Cγ) in six simulated systems: FKBP12-ALK2^WT; ALK2^WT; FKBP12-ALK2^WT-Phosp; ALK2^WT-Phosp; FKBP12-ALK^Q207E; and FKBP12-ALK2^R206H.

The right panels are the distribution of the distances over the whole trajectories. R375(Cζ)-D354 (Cγ) distance below 5 Å represents salt bridge forming.

doi: https://doi.org/10.1371/journal.pcbi.1005711.g002