Two passive mechanical conditions modulate power generation by the outer hair cells
Fig 8
Sensitivity analysis of the model.
Each data point represents the amplification factor near x = 6 mm with only one model parameter changed from its standard value. (A) Effect of component stiffness on amplification. The OCC structures include the outer hair cell body (OHC), outer hair cell stereocilia (OHB), and other structures (Other: the Deiters cell, Deiters cell process, pillar cell, and reticular lamina). Tested values of Young’s modulus of each component range from 1/8 to 8 times the standard value. (B) Effect of damping on amplification. (C) Effect of the active feedback gains on amplification. Note that the x-axis has a log-scale in (A) and (B), but a linear-scale in (C). The normalized stiffness, damping, and active gain are defined as the altered value divided by the standard value used in the model. Standard values for stiffness and active gain are given in Table 1. Standard values for damping are discussed in the Methods section.