Upregulation of an inward rectifying K+ channel can rescue slow Ca2+ oscillations in K(ATP) channel deficient pancreatic islets
Fig 7
Fura-2 Ca2+ measurements of islets in 11 mM glucose and, as indicated, 50 μM of the membrane permeable 8-Br-cAMP.
(A) Ca2+ oscillations in wild-type islets persist with little or no change upon application of 8-Br-cAMP. Representative of 10 islets. (B) Ca2+ oscillations in SUR1-/- islets are terminated by 8-Br-cAMP, and Ca2+ is at a low level. Representative of 9 islets.