Upregulation of an inward rectifying K+ channel can rescue slow Ca2+ oscillations in K(ATP) channel deficient pancreatic islets
Fig 6
In the model KO cells, bursting is driven by the Kir2.1 current, which is regulated by voltage and the cAMP concentration.
(A) Mean V and c during a burst. Voltage is averaged over each spike. (B) The cAMP and cytosolic AMP concentrations. (C) Dynamics of the Kir2.1 channel activation (c∞) and inactivation (k∞). (D) Kir2.1 conductance during a burst.