Upregulation of an inward rectifying K+ channel can rescue slow Ca2+ oscillations in K(ATP) channel deficient pancreatic islets
Fig 4
Bursting in wild-type model cells.
Slow glycolytic oscillations drive bursting through actions on the K(ATP) current. (A) cAMP declines at the start of each Ca2+ plateau. (B) K(ATP) channel conductance. (C-D) Adenine nucleotide concentrations in the cytosol. (E) Slow glycolytic oscillations are reflected in the FBP time course.