Interactions between the tumor and the blood systemic response of breast cancer patients
Fig 6
Significant Matched Interactions across Tissue (MIxT) in basalL patients.
(A) The figure summarizes the two sets of significant MIxT in basalL patients detailed in Fig 6A and 6C. Top pathway enrichment keywords are presented for each module. Red and blue arrows correspond to negative and positive correlations between ranksums, respectively. (B) MIxT in basalL patients between the brown tumor module and the darkgreen SR module. Heatmaps are ordered by ranksum of gene expression in the brown tumor module. Asterisks represent the level of significance of the associations between the gene ranksums for the brown tumor module and clinicopathological attributes of patients (fdr < **0.05). Associations were estimated using ANOVA and Pearson correlation for categorical and continuous variable, respectively. Boxplots show the distribution of ranksums for the SR module in patients classified according to their ROI95 tumor module category and controls. (C) The second set of MIxT in basalL patients between the darkgreen tumor module and four SR modules (darkgreen, green, greenyellow, darkgrey). Legend follows Fig 6B.