Interactions between the tumor and the blood systemic response of breast cancer patients
Fig 5
Association between the brown tumor and green SR module for two distinct subtypes.
(A) Scatter plot of ranksums of the brown tumor module and the green SR module in ER-/HER2- patients. The top corner depicts the background distributions of the correlations coefficients between ranksums of every modules pairs across tissues in ER-/HER2- patients. (B) Scatter plot of ranksums of the brown tumor module and the green SR module in ER+/lumB patients. Legend follows Fig 5A (C) Expression heatmap of genes in the brown tumor module in ER-/HER2- patients. Patients are linearly ordered based on the ranksum of gene expression in the brown tumor module. Yellow vertical lines delimit the ROI95 in tumor that contains 95% of the randomly generated samples. Genes that are positively and negatively correlated with the ranksum are represented in the right sidebar colored in red and blue, respectively. Top pathway enrichment keywords and representative genes are indicated on the left and right of the heatmap, respectively). (D) Expression heatmap of genes in the brown tumor module in ER+/lumB patients. Legend follows Fig 5C. (E) Expression heatmap of genes in the green SR module in ER-/HER2- patients. Legend follows Fig 5C. Top pathway enrichment keywords and representative genes are indicated on the left and right of the heatmap, respectively. (F) Expression heatmap of genes in the green SR module in ER+/lumB patients. Legend follows Fig 5E. (G) Clinical characteristics of ER-/HER2- patients ordered by the ranksum of gene expression in the brown tumor module. Legend follows Fig 1D. (H) Clinical characteristics of ER+/lumB patients ordered by the ranksum of gene expression in the brown tumor module. Legend follows Fig 1D. Asterisks represent the level of significance of the associations between the gene ranksums for the brown tumor module and clinicopathological attributes of patients. Associations were estimated using ANOVA (fdr < ***0.01). (I) Distribution of ranksums for ER-/HER2- patients and controls induced by the expression of genes in the green SR module. Patients are grouped according to the ROI95 brown tumor module category as defined in Fig 5C. aov: analysis of variance (J) Distribution of ranksums for ER+/lumB patients and controls induced by the expression of genes in the green SR module. Patients are grouped according to the ROI95 brown tumor module category as defined in Fig 5D.