Interactions between the tumor and the blood systemic response of breast cancer patients
Fig 3
Modules size and overlap in their gene composition across tissues.
(A) Histograms depicting number of genes composing modules in each tissue. Edges between modules indicate significant overlaps in gene composition (Fisher exact test, fdr < 0.01). (B) Expression heatmaps of the 47 genes included in both darkturquoise modules in tumor (upper) and SR (lower). Patients in both heatmaps are linearly ordered based on their ranksum of gene expression in tumors. Yellow vertical lines delimit the region of Independence (ROI95) in tumor that contains 95% of randomly generated samples. Twenty genes out of the 47 common genes are involved in the type 1 IFN signaling pathway (IFN alpha signaling pathway is depicted on the right).