Bow-tie signaling in c-di-GMP: Machine learning in a simple biochemical network
Fig 3
Bow-tie model of biochemical reactions in the c-di-GMP network explains mutants of PA14 evolved in the laboratory.
A: Diagram of the bow-tie model showing the α and β coefficients for sensor and effector modules. B-D: A water tank diagram explains how the relative values of c-di-GMP and the effector setpoint lead to the specialist phenotypes for mutants (C,D) evolved from a generalist laboratory strain (PA14) in laboratory experiments (B).