Recurrently connected and localized neuronal communities initiate coordinated spontaneous activity in neuronal networks
Fig 7
The pre-NB activity shares similar temporal motifs for NBs in the same class and is informative of the following coordinated event.
(A) Illustrative representation of the analysis chain used for the pre-NB temporal motifs, where we considered the following: two NBs (α,β), their pre-NB activity (αPRE,βPRE), the NB-graphs (αG,βG), the largest connected components (αL,βL) and the corresponding number of spikes in the shared temporal motifs (αM,βM, M = 12 spikes). (B) All NBs of the same cluster (e.g., cluster ID 0) share common pre-NB temporal motifs (cyan spikes). For instance, the NB occurring at time t0 shares a temporal motif with the event at time t1 but differs from the temporal motif shared between NBs occurring at time t2 and t3. (C) Normalized similarity matrix among pre-NBs activities (M-motif, with M > 5) for clustered NBs. The clustered NBs share the highest number of motifs (i.e., higher values on the diagonal), indicating that the pre-NB activity is informative of the following NB. (D) Cumulative similarity plot corresponding to the data in panel C but normalized with respect to the cluster size (per-cluster, dashed line) or to the total number of NBs (solid lines). The similarity is consistently higher for the pre-NB activity of NBs belonging to the same cluster (IN) than for the NBs of other clusters (ACROSS). (E) Reordered similarity matrix of pre-NB activity of a simulated network, showing a block structure. Each block is relative to an NB cluster characterized by similar pre-NB spiking patterns. (F) Reordered similarity matrix of recorded pre-NB activity in a cultured network, still shows a block structure.