Recurrently connected and localized neuronal communities initiate coordinated spontaneous activity in neuronal networks
Fig 4
Network regions initiating spontaneous NBs correspond to functional communities.
Spatial maps of the functional communities (fCOMs) and CATs (for clarity, CATs are only depicted up to 50 ms after NB initiation) computed for NBs in simulations (A) and recordings (B), show that the ignition sites (ISs, blue dots) of the NBs and the fCOMs (regions delimited by black solid curves) tend to overlap. A further quantification confirms that the overlap is statistically significant. (C) Fraction of NBs with ISs in a specific fCOM over the total number of NBs, for simulated (black) and experimental (blue) data. (D) Fraction of NBs with ISs located in an area defined by an increasing number of fCOMs (‘area covered’) over the total number of NBs (black: n = 20 simulations, blue: n = 15 recordings, mean value: solid line, standard deviation: shaded area). As shown, NBs originate from <50% of the network area. (E) Boxplots of simulated and experimental areas covered by fCOMs with respect to the total network area, showing that even though not all fCOMs are associated with an IS, the mean total area covered by all fCOMs is <40%.