Reconstructing the regulatory circuit of cell fate determination in yeast mating response
Fig 5
Dose-dependent regulation patterns and mechanism for cell fate determination.
(A) Regulation modes of the 6 gene groups in elongated cells (colored in blue), and in shmooing cells (colored in red). The activity of each cluster was averaged from all of the gene-specific regulation information for the corresponding genes, with regulation level normalized to 1/-1 for activation/inhibition. Several clusters show divergent behaviors in the two phenotypes, as in observed for C1 and C3, which contributes to the differential regulation that determines the cell fate switching. Schematic illustration of active gene groups and regulatory circuits responsible for different cell fates, including vegetative growth (B), elongated growth (C) and shmooing (D). Edges that result in the activation/ inhibition of gene groups are illustrated.