Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach
Fig 10
Bacteria in all subpopulations increase more slowly following MXF treatment interruption, compared to GFX and LVX (A-D). Lines show means of 210 in silico granulomas, with infection starting at day 0, daily FQ treatment starting at day 380 (arrows). Treatment is interrupted after 10 days (vertical dotted lines), and the simulation is continued to day 560 without antibiotics. (E-F) Immune score (x-axes) and infection score (y-axes) decrease during complete treatment (E) and rebound following treatment interruption after 10 days (F). The start of treatment is located at the intersection of the dotted lines. Filled circles indicate the treatment phase, and open circles indicated progression following treatment interruption.