Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach
Fig 6
Simulated average free FQ concentrations that each bacterial subpopulation (intracellular (A), extracellular (B) and nonreplicating (C)) is exposed to during one dosing period.
Solid lines show means and dashed lines show standard deviations for 210 in silico granulomas. Horizontal dotted lines show C50 values for intracellular (C50,BI), extracellular replicating (C50,BE) and extracellular non-replicating bacteria (C50,BN) for each FQ.