Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach
Fig 3
Comparison of average FQ concentrations in simulated granulomas (solid lines) recapitulate LCMS measurements in rabbit granulomas (data points).
Lines and data points show means and standard deviations for 100 in silico granulomas, and between 1 and 67 rabbit granulomas. Horizontal dotted lines show C50 values for intracellular (C50,BI), extracellular replicating (C50,BE) and extracellular non-replicating bacteria (C50,BN). Though not used for model calibration, dynamics in uninvolved lung are also in agreement between simulations and rabbit data (Figure in S2 Fig).