MrTADFinder: A network modularity based approach to identify topologically associating domains in multiple resolutions
Fig 2
Identification of TADs in multiple resolutions.
A) A part of the contact map of the chromosome 10 in hES cell. The greenish triangles below represent TADs called by MrTADFinder in three different resolutions. The TADs called agree well visually with the contact map. The blue triangles and red triangles represent TADs called in human ES cells and human IMR90 cells respectively as reported in [8]. B) The size of TADs called in different resolutions. The median TADs size decreases from 3 Mbp to 300 kbp as the resolution increases from 0.75 to 3.5. C) The number of TADs increases as the resolution increases. When γ = 2.25, there are about 2600 TADs in hES cells with a median size of roughly 1Mb. The median size goes down to 300kb when the resolution increases to 3.5. The number of TADs identified in [8] is marked by the arrow. Comparing TADs called by MrTADFinder with TADs called in [8]. Two algorithms agree the most in a particular resolution (γ ≈ 2.875).