Classification and analysis of a large collection of in vivo bioassay descriptions
Fig 9
Major component of the animal model—Drug network with detailed “diabesity” cluster.
The nodes in the graph correspond to approved drugs and animal models of disease, including induced, spontaneous, and transgenic disease models text-mined from assay descriptions. A drug is linked to an animal model if it was tested in at least five assays involving this model. Drug nodes are colored according to the assigned ATC (level 2) codes, while animal model nodes are blue; node size is proportional to the number of assays involving a given drug or model. Animal model-drug relationships visualized in the graph are listed in the S5 Dataset. STZ, streptozotocin-induced model; GTT, glucose tolerance test; ZDF, Zucker Diabetic Fatty rat; glucose, glucose-loaded model.