Classification and analysis of a large collection of in vivo bioassay descriptions
Fig 6
Semantic similarities between animal models and phenotypes.
A hierarchically clustered heatmap showing pairwise semantic similarities between 35 animal models and 35 phenotypes frequently mentioned in the assay descriptions. Red color corresponds to higher, blue—to lower semantic similarity; values in each row are Z-score normalized. Both rows and columns are hierarchically clustered (using average linkage and Euclidean distance) and the results are represented as dendrograms. Semantic clusters, shown as red regions on the heatmap, correspond to distinct disease areas including epilepsy, pain, inflammation, hypertension, diabesity, and cancer. The figure provides an automatically-generated summary of the use of common animal models to study the effect of drugs on different types of disease-related phenotypes.