Classification and analysis of a large collection of in vivo bioassay descriptions
Fig 5
Most common rodent strains and experimental disease models mentioned in the descriptions of in vivo efficacy assays in ChEMBL.
(A) Twenty strains that are most frequently mentioned in assay descriptions; outbred strains are marked with an asterisk (*). Upon identification in the text of assay descriptions, the strain names were normalized using strain synonym listings maintained by rodent genome databases. For instance, C57BL mouse was described in various descriptions with more than 30 different terms including names that do not follow official nomenclature guidelines: “BL6”, “Black6”, or “C57/Black”. (B) Bar plot showing twenty experimental models that are most frequently mentioned in assay descriptions. The models were manually annotated with disease area.