Identifying direct contacts between protein complex subunits from their conditional dependence in proteomics datasets
Fig 6
Prediction of direct contacts between subunits of the 26S proteasome.
A. Matrix of true contacts (upper right, derived from PDB entry 4CR2 [47]) and correlation coefficients (lower left) for the 26S proteasome. Correlation identifies general sub-complex structure but fails to discriminate between direct and indirect interactions (6 out of top 10 predictions correct). B. Matrix of true contacts (upper right) and direct contact predictions (lower left) for the 26S proteasome. The direct contact method identifies many true contacts while strongly reducing the number of false positive predictions (9 out of top 10 predictions correct).