Flux balance analysis predicts Warburg-like effects of mouse hepatocyte deficient in miR-122a
Fig 2
Similarity ratio of 20 miR-122a target enzymes to Warburg effect and experimental metabolic profiling observations (LC/MS).
The similarity ratio of each target gene was calculated to indicate that how many percentages for the computational predictions (100% overexpression) are similar to the hypothesis of the Warburg effect (blue line) and experimental metabolic profiling observations (pink line). The Ddc gene received the highest similarity ratio to the Warburg effect (0.952) and experiments (0.75) (a, 54% overexpression; b, downregulation; c, knockout; d, overexpression of forward and reverse reactions).