Systematic, network-based characterization of therapeutic target inhibitors
Fig 4
Comparison of CMoA, GES and GI50 profile similarities.
(A) Venn diagram of the top 206 similar compound pairs (top 2.5%) using DTPA, DTGE and GI50 sensitivity profiles. (B) top: Enrichment of the top 206 pairs based on DTPA similarity in the vector of 8256 (129*128/2) compound pairs ranked by DTGE similarity, and vice versa; middle: Enrichment of the top 206 pairs based on DTPA similarity in the vector of 8256 (129*128/2) compound pairs ranked by GI50 correlation, and vice versa; bottom: Enrichment plot of the top 206 pairs using DTGE similarity in the vector of 8256 (129*128/2) compound pairs ranked by GI50 correlation, and vice versa.