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Reduction of multiscale stochastic biochemical reaction networks using exact moment derivation

Fig 6

Period distributions of full and reduced models.

(A) Fourier transforms of stochastic trajectories with about 104 cycles of the EMB model, the AMB model and the full model with ϵ = 0.1. (B) After partitioning the trajectory of 104 cycles into 2⋅103 trajectories so that each trajectory consists of about 5 cycles, the autocorrelation of each trajectory is calculated to estimate the period of each trajectory. The period distribution of 2⋅103 trajectories of the EMB model (above) better captures that of the full model with ϵ = 0.1 than that of the AMB model (bottom). (C-D) The mean and the standard deviation of period distributions of the EMB model, the AMB model, and the full model with ϵ = 10, 1, 0.1.

Fig 6

doi: https://doi.org/10.1371/journal.pcbi.1005571.g006