Reduction of multiscale stochastic biochemical reaction networks using exact moment derivation
Fig 4
The EMB model provides more accurate approximation of the transcriptional negative feedback loop model than AMB model.
(A-B) Trajectories of the full model with ϵ = 0.01 and the EMB model (A) and the AMB model (B). The lines and colored ranges represent E(XR: R) and E(XR: R) ± SD(XR: R)/2 of 104 stochastic simulations. Here Xi(0) = 0. (C-D) Mean (C) and standard deviation (D) of steady state distribution of the full model with varying ϵ = 0.1, 0.05, 0.01, the EMB model and the AMB model.