Reduction of multiscale stochastic biochemical reaction networks using exact moment derivation
Fig 3
Model diagram of a transcriptional negative feedback loop with a fast feedfoward subnetwork and a slow dimerization.
In the diagram of the full model (top), red arrows indicate fast reactions. Note that the subnetwork consisting of the fast species E, Q, F, and R with fast reactions (red arrows) is feedforward. In the diagram of the reduced model (bottom), which solely consists of slow species and slow reactions, 〈R(R − 1)〉 represents a conditional moment, 〈XR(XR − 1)|XP〉. In both of the diagrams, all degradation reactions are not shown, for simplicity.