Chemomechanical regulation of myosin Ic cross-bridges: Deducing the elastic properties of an ensemble from single-molecule mechanisms
Fig 9
Diagram modified from Fig 1 to calculate the average time in different states.
(a) To determine the time that myosin spends in the strongly bound states, we promote state (1) and (2) to absorbing states by eliminating the transitions from these states. (b) A closed diagram is obtained from (a) by redirecting the arrows into the absorbing states (1) and (2) back to the starting states (3) and (5) weighted with the starting probabilities π3 and (1 − π3), respectively. In the same manner, we construct the diagrams shown in (c) and (d) to determine the time that myosin is attached to actin.