Chemomechanical regulation of myosin Ic cross-bridges: Deducing the elastic properties of an ensemble from single-molecule mechanisms
Fig 5
The modeled probability Psb of occupying the strongly bound states and the probability Pon of being bound to actin.
(a,c) Changing the nucleotide concentrations or (b,d) the actin concentration is qualitatively similar for probabilities Psb and Pon; an increased ADP concentration increases both probabilities. More actin in the vicinity of myosin also enhances both probabilities. However, the probability Psb of occupying strongly bound states saturates and is then limited by Pi binding, whereas the probability Pon of being bound to actin reaches unity for high actin concentrations.