< Back to Article
Chemomechanical regulation of myosin Ic cross-bridges: Deducing the elastic properties of an ensemble from single-molecule mechanisms
Fig 2
The nucleotide-dependent unbinding rate of a single myosin Ic head from the strongly bound states as a function of force.
In (a), we fit the theoretical unbinding rate 
(Eq 53) (solid lines) to the experimental data (dots) for two different nucleotide concentrations. The orange and blue areas around the experimental data represent the 95% confidence intervals. The parameter values from this fit are summarized in Table 1 and the experimental data have been published [20]. (b) The modeled unbinding rate 
as a function of force F for different nucleotide concentrations. Although an increased Pi concentration has no effect compared to (a), raising the ADP concentration reduces the unbinding rate. This reduction can be reversed by increasing the ATP concentration.
doi: https://doi.org/10.1371/journal.pcbi.1005566.g002