Novel mRNA-specific effects of ribosome drop-off on translation rate and polysome profile
Fig 1
Main characteristics of the TASEP model.
(a) Phase diagram. A low density (LD) phase, with density ρ < 1/2, arises when the current is limited by the input rate α. Symmetrically, a high density (HD) phase, with ρ > 1/2 is observed when the flow is governed by the output rate β. When neither is limiting, in the ‘maximal current’ phase (MC), the current is as large as the hopping process in the bulk permits (J = k/4 for ρ = 1/2). The line separating the LD and HD phases is where a shock phase (SP) is observed, where LD and HD zones coexist along the lattice. In this case the (few) sites corresponding to the interface between these these two zones is known as the ‘domain wall’. (b)-(e) Density profiles ρi of the original TASEP for a lattice of N = 500 sites and hopping rate k = 1. (b): LD regime: α = 0.2, β = 1; (c): HD regime: α = 1, β = 0.1; (d): MC regime: α = β = 0.5; (e): SP regime: α = β = 0.3. The solid black line represents the analytical solution from the mean-field approximation, and the blue points correspond to numerical simulations using the Gillespie algorithm [41].