Brain network eigenmodes provide a robust and compact representation of the structural connectome in health and disease
Fig 7
Effect of corpus callosum on connectome eigenmodes.
Top) brain network architecture determined by averaged connectomes from eleven healthy adults for the control, seven cases of complete agenesis of corpus callosum (AgCC), and the same eleven healthy adults with virtual callosotomies. Note how the second eigenmode in all three cases represents diffusion between both hemispheres, albeit more polarized in cases of AgCC and virtual callosotomies, due to the lack of an intact corpus callosum. For higher eigenmodes, we see that each eigenmode in the control group is split into two separate modes in the AgCC or virtual callosotomy cases, one for each hemisphere. Intuitively, the corpus callosum synchronizes diffusion across both hemispheres, and its absence allows transmission to occur within one hemisphere with no effect on the other which is reflected in the changed eigenmodes. Bottom) the eigenvalue corresponding to the speed of diffusion in the second eigenmode (left-right communication) is shown along with 95% confidence bounds. All differences in eigenvalues are statistically significant.