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Multi-scale computational study of the mechanical regulation of cell mitotic rounding in epithelia

Fig 8

Quantitation of relative sensitivity of mitotic area expansion and roundness to adhesion, stiffness and pressure changes within the physiological property space.

Sensitivity estimation of (A) (A_mit/A_inter) and (B) R_norm to small perturbation in the three mitotic parameter set points, , , and ΔP. Sensitivity was estimated from the reduced RSM model described in Fig 7C–7F after stepwise model regression (p-value cutoff of 0.01). (C) Proposed mechanical regulatory network defined for “physiological ranges” within the parameter ranges defined by the CCD (Run 2, Fig 7A) that summarizes the local sensitivity analysis. Cell adhesivity, an increase in , slightly inhibits area expansion and strongly inhibits roundness. Membrane stiffness, inhibits area expansion and promotes roundness. Mitotic area expansion is most sensitive to variation in the mitotic pressure change (ΔP), but pressure has little effect on roundness over the calibrated physiological ranges.

doi: https://doi.org/10.1371/journal.pcbi.1005533.g008