Multi-scale computational study of the mechanical regulation of cell mitotic rounding in epithelia
Fig 6
Emergence of tissue-level statistics from model simulations.
(A) Sample simulation output showing cells with different numbers of neighbors as different colors (B) Simulations initiated from seven cells reaches steady-state polygon-class distribution after approximately 35 hours of cell proliferation. (C) Comparison of polygon class distributions obtained by Epi-Scale model with various biological systems (data extracted from [79]) and a vertex based model by Farhadifar et al. [38]. (D) Polygon class distribution of cells at different stages of growth, and comparison of mitotic cells distribution with Drosophila wing disc experimental data [63]. (E) Polygon class distribution of cells at different level of cell’s elasticity. The results do not show sensitivity in the range of reported elasticity of epithelial cells [67]. (F) Average relative area (), and average polygon class of neighboring cells verifying that simulation results satisfy Lewis law and Aboav-Weaire law. A is the apical area of cell and
is the average apical area of the population of cells.