Multi-scale computational study of the mechanical regulation of cell mitotic rounding in epithelia
Fig 3
Initial conditions and sample simulation output.
(A) Initial condition of a simulation with seven initially non-adherent circular cells. Each cell starts with 100 membrane elements and 20 internal elements. (B) Initial formation of an epithelial sheet after cells adhere to each other. An equilibrium distribution of internal nodes is reached for each cell. (C) Epithelial sheet after 55 hours of proliferation. (D) Enlarged view of the selected region showing different cell shapes and sizes due to interactions between cells. The large cell is undergoing mitotic rounding (MR).