An agent-based model of leukocyte transendothelial migration during atherogenesis
Fig 2
Protein diffusion and leukocyte chemotaxis.
2D example of leukocyte (yellow circle with blue outline) migration. Color bar represents the cytokine concentration gradient (black (highest) to white (lowest) via gray). Yellow agents produce the cytokines. At tick 0 the leukocyte is 5 patches away from the source. Cytokines diffuse at each tick following Fick’s law. At tick 4, the leukocyte moves to its topmost neighboring patch, since that patch has the highest cytokine concentration and space available. In next ticks, the leukocyte surveys it’s neighboring patches and moves to the one with space available and the highest concentration. At tick 8, it has reached the patch with the highest concentration (darkest). Each tick represents 1 hr.