Erroneous energy-generating cycles in published genome scale metabolic networks: Identification and removal
Fig 3
The majority of metabolic network reconstructions in two of the examined databases (ModelSEED and MetaNetX) contain erroneous internal EGCs that generate energy.
In contrast, most models in BiGG do not contain EGCs. Total bar size reflects the number of models contained in each database. Green: models without EGCs; purple: models with EGCs that could be corrected through GlobalFit; orange: models with EGCs that cannot be corrected through reaction removals.