Effect of transcription factor resource sharing on gene expression noise
Fig 1
Different scenarios of competition for a pool of TFs among promoters and other binding sites.
(A) A single promoter copy in isolation without the presence of any other TF binding sites. (B) Multiple copies of identical promoters competing with each other for the TFs. (C) Promoters compete with other competitor sites for the TFs. Competitor sites can correspond to ‘decoy sites’ or promoters driving expression of other gene species. Therefore, although the competitor sites bind to the TFs, they do not regulate the production of mRNA molecules from the target promoters.