Combining inferred regulatory and reconstructed metabolic networks enhances phenotype prediction in yeast
Fig 6
Synthetic growth defect interactions identified by IDREAM.
A. Growth defect confidence scores measured by ODELAY. Beyond the genetic interactions between OAF1 and genes encoding components of the pyruvate dehydrogenase (PDH) complex, ODELAY also validated the predicted genetic interaction between CIN5 and GRX5, but did not confirm the remaining 3 of the 9 predictions. B. ROC curve describing identification of IDREAM or control strains based on ODELAY scores.