Combining inferred regulatory and reconstructed metabolic networks enhances phenotype prediction in yeast
Fig 3
MCCs between predicted and experimental growth changes across different media and at different thresholds for binarizing a call as “growth defect” or “no growth defect”.
Four conditions are presented in the four panels (A, B, C and D). Under each condition, we calculated the ratio of growth rates between TF knockout and wild-type. When the ratio was lower than some particular threshold, the corresponding TF is considered growth defective. By adjusting the threshold of growth ratio from 0.1 to 0.95, the MCCs between prediction and measurement were derived. A. Glucose minimal medium with ammonium. B. Galatose with ammonium medium. C. Glucose with urea medium. D. Combining the three media.