Functional asymmetry and plasticity of electrical synapses interconnecting neurons through a 36-state model of gap junction channel gating
Fig 9
Simulation of [Mg2+]i–mediated changes of junctional conductance (black traces) measured in RIN cells expressing Cx36.
A) [Mg2+]i decreased from 1 to 0.01 mM. The fitted junctional conductance (gj) kinetics (red trace) was obtained at ~4.5-fold V0 increase and ~1000-fold pc1→c2 decrease. Blue traces and the right Y axis show the fraction of closed gap junction channels in which at least one slow gate is in a deep-closed state (solid blue trace). B) The same as in A, but [Mg2+]i increased from 1 to 5 mM. The fitted red trace was obtained when V0 decreased ~2 fold, while pc1→c2 rose from 0.7 to 0.95. In both A and B, gj values were normalized at [Mg2+]i = 1 mM.