Functional asymmetry and plasticity of electrical synapses interconnecting neurons through a 36-state model of gap junction channel gating
Fig 8
Neuronal activity-dependent changes of junctional conductance in heterotypic gap junctions.
A) Simulated steady-state conductance–voltage (gj,st–Vj) relationship of heterotypic gap junctions that resembles experimentally measured gj,st–Vj relationship of Cx43/Cx45 gap junctions. B shows the transfer of action potentials when the cell, virtually expressing Cx45, was stimulated. B-a) Records of membrane voltage responses in cell-Cx45 (blue trace) and cell-Cx43 (red trace). B-b) Transjunctional voltage (Vj) spikes developed in the electrical synapse. B-c) Changes of junctional conductance (gj) caused by the spiking activity of neurons. C-a,b,c) The same as in B-a,b,c, but a cell, virtually expressing Cx43, was stimulated.