Highly accessible AU-rich regions in 3’ untranslated regions are hotspots for binding of regulatory factors
Fig 4
PolyA complex RBPs are enriched on distal hisites.
CLIP enrichment of RBPs from the polyA complex around proximal (blue), medial (green) and distal (yellow) hisites. All the RBPs show a higher enrichment on distal hisites compared to proximal and medial hisites. These binding profiles can be grouped in two categories. In the first group, which includes CF-Im25, CF-Im59, CF-Im68, CPSF-160 and Fip1, the profiles are similar to that of AGO2. In the second set, which includes CstF-64 and WDR33, the enrichment changes from low to high across hisites.