Modelling T cell proliferation: Dynamics heterogeneity depending on cell differentiation, age, and genetic background
Fig 7
Quantification of dividing cells during thymocyte differentiation.
For each stage of thymocyte differentiation, the number of cells and the number of EdU+ cells (in millions) is quantified by FACS after pulse/chase. The correlation between these numbers is shown according to strains and ages of mice (upper panel). Box plots represent the quartiles and the lines represent the evolution of the median values through stage of differentiation thus across time, in four mice per group (lower panel). DN CD3- cells are in yellow, DP cells are in red and decomposed into DPearly (CD4hiCD8hi) and DP late (CD4medCD8med). Then DP cells differentiate either into CD4+CD3+ (blue) or into CD8+CD3+(green) mature T cells.