Modelling T cell proliferation: Dynamics heterogeneity depending on cell differentiation, age, and genetic background
Fig 6
Signatures of lymphocyte proliferation according to strains and ages.
The upper panel shows the correlation between the percentages of EdU+ cells observed 16 h after the pulse/chase/pulse experiment in thymus of B6 and FVB mice (80 values) and according to the age of mice (2 months: blue circle, 18 months: red circles). Hierarchical unsupervised clustering showing the clusters of mice according to the rates of proliferation. Values and statistics are given in S1, S2, S3 and S4 Tables. Proliferation rates/day are significantly different (p<0.05) comparing: In thymus: B6 2M vs B6 18M: 2M>18M in DP, CD8; FVB 2M vs FVB 18M: 2M>18M in DN and CD4; B6 2M vs FVB 2M:B6>FVB in DP CD3+, CD8; B6 18M vs FVB 18M:B6>FVB in CD8. In spleen: B6 2M vs B6 18M: 2M>18M in CD4 CD44hi; FVB 2M vs FVB 18M: 2M>18M in CD4 CD44hi;B6 2M vs FVB 2M:B6>FVB in CD4, CD4 Foxp3+; B6 18M vs FVB 18M:B6>FVB in CD4 Foxp3+, CD8 CD44hi