Modelling T cell proliferation: Dynamics heterogeneity depending on cell differentiation, age, and genetic background
Fig 5
Validation of the mathematical model and parameter values with pulse/chase experimental data from [15].
Young B6 mice received a single BrdU pulse, and within the BrdU-labelled cells the percentages of cells in GO/G1, S or G2/M is recorded over a nineteen hour chase period. The points and dashed lines represent Baron experimental data. Simulation of the same pulse chase conditions using our mathematical model, with the mean parameter values (S1 Table) obtained from our 2-month-old B6 mice (n = 4). The points and continuous lines represent the results of our simulation.