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Modelling T cell proliferation: Dynamics heterogeneity depending on cell differentiation, age, and genetic background

Fig 2

Thymocyte proliferation in mice according to cell differentiation stage, age and genetic origin.

Cell proliferation was assessed in C57BL/6 and FVB mice of 2 or 18 months as in Fig 1. (A) Multi-colour flow cytometry and hierarchical gating in thymocytes showing EdU vs DNA content dot plot in 2-month-old mice. (B) Percentage of EdU⁺ labelled cells according to differentiation stages through time: from the most immature CD3^-CD4^-CD8^- triple negative cells (TN), CD3^loCD4⁺CD8⁺ double positive cells (DP CD3^lo), CD3^hiCD4⁺CD8⁺ double positive cells (DP CD3^hi) to single positive mature CD4⁺CD3⁺ or CD8⁺CD3⁺stage. Each curve represents the %EdU uptake for one of the 4 mice per group.

doi: https://doi.org/10.1371/journal.pcbi.1005417.g002